High Protein Spinach and Artichoke Chicken Casserole

If you enjoy easy high-protein chicken dinners, you may also like this High-Protein Chicken Parm Bowl in 15 Minutes.

• 2 cups cooked shredded chicken
• 1 cup fresh spinach, chopped
• 1 can (14 oz) artichoke hearts, drained and chopped
• 1 cup plain Greek yogurt
• 1 cup shredded mozzarella cheese
• 1/2 cup grated Parmesan cheese
• 1 teaspoon garlic powder
• 1 teaspoon onion powder
• 1/2 teaspoon salt, or to taste
• 1/4 teaspoon black pepper, or to taste
• 1/2 cup breadcrumbs, optional

Chicken: Rotisserie chicken is the easiest option because it is already cooked and easy to shred. You can also use leftover baked or roasted chicken.

Greek yogurt: Plain Greek yogurt creates the creamy base while keeping the recipe lighter than a traditional cream-based casserole. Full-fat, low-fat, or non-fat Greek yogurt can be used.

Spinach: Fresh spinach works well, but frozen chopped spinach can also be used. Thaw it completely and squeeze out as much water as possible before adding it.

Artichoke hearts: Drain the artichokes very well and pat them dry with paper towels. Excess moisture can make the casserole watery.

Mozzarella: Shredding mozzarella from a block can give you a smoother melt. Pre-shredded mozzarella also works when convenience is more important.

Parmesan: Freshly grated Parmesan gives the topping a stronger savory flavor, but packaged grated Parmesan can also be used.

Breadcrumbs: Breadcrumbs are optional. Leave them out for a lower-carb version, or replace them with almond flour for a gluten-free crunchy topping.

Seasonings: Garlic powder and onion powder keep the seasoning simple. Add Italian seasoning, black pepper, or red pepper flakes if you want more flavor.

Extra heat: A pinch of red pepper flakes or cayenne can add a little heat to the creamy filling.

Step 1: Preheat the Oven

Preheat your oven to 375°F (190°C).

Lightly grease a 9 × 13-inch baking dish with cooking spray or a small amount of oil.

Preheating the oven before assembling the casserole helps it bake evenly and allows the cheese to melt properly.

Step 2: Prepare the Chicken Mixture

Add the shredded chicken, chopped spinach, drained artichoke hearts, Greek yogurt, garlic powder, onion powder, salt, and black pepper to a large mixing bowl.

Stir until the ingredients are evenly combined and the chicken is coated with the creamy Greek yogurt mixture.

Step 3: Add the Cheese

Stir in 1/2 cup of the shredded mozzarella and the grated Parmesan.

Reserve the remaining mozzarella for the top of the casserole.

Mix gently until the cheese is distributed throughout the chicken mixture.

Step 4: Transfer to the Baking Dish

Spread the mixture evenly into the prepared baking dish.

Use the back of a spoon or spatula to smooth the surface so the casserole bakes evenly from edge to edge.

Step 5: Add the Topping

Sprinkle the remaining mozzarella evenly over the top.

If using breadcrumbs, sprinkle them over the cheese.

The breadcrumbs are optional, but they add a light crunchy texture to the creamy casserole.

Step 6: Bake

Place the casserole in the preheated oven and bake for 25–30 minutes, or until the cheese is melted, bubbling, and lightly golden around the edges.

For a deeper golden top, you can broil the casserole for about 1 minute at the end. Watch it closely because the cheese can brown quickly.

Step 7: Rest and Serve

Remove the casserole from the oven and let it rest for about 5 minutes before serving.

This short resting time allows the creamy filling to settle and makes the casserole easier to portion.

• Drain and pat the artichoke hearts dry to prevent excess moisture.
• If using frozen spinach, squeeze out as much water as possible after thawing.
• Rotisserie chicken is a convenient shortcut for this recipe.
• Use freshly shredded mozzarella for a smooth, even melt.
• Do not skip the short resting period after baking.
• Add red pepper flakes if you prefer a little heat.
• For extra creaminess, stir the Greek yogurt well before combining it with the chicken.
• Broil for about 60 seconds at the end if you want a more deeply browned cheese topping.

For another comforting high-protein dinner, try this High-Protein Creamy Cajun Chicken with Garlic Rice.

This casserole is filling on its own, but it also pairs well with simple sides.

• Serve with a crisp garden salad and light vinaigrette.
• Pair with roasted asparagus or steamed broccoli.
• Serve with roasted green beans for an easy vegetable side.
• Add a small portion of quinoa for a heartier meal.
• Serve with toasted sourdough or garlic bread if you want a more substantial dinner.
• Add sliced cucumber or tomatoes for a fresh side.

If you want another high-protein casserole for your dinner rotation, try this Easy Low-Carb Ground Turkey Zucchini Casserole.

Store leftover casserole in an airtight container in the refrigerator for up to 3–4 days.

For individual portions, microwave for about 60–90 seconds, then continue heating in short intervals until warmed through.

You can also reheat the casserole in a 350°F oven until hot.

For meal prep, divide the casserole into individual containers after it has cooled and refrigerate.

Freezing is not recommended for the best texture because the Greek yogurt-based filling can separate after freezing and thawing.

Can I make this casserole ahead of time?

Yes. Assemble the casserole in the baking dish, cover it, and refrigerate it for up to 24 hours before baking.

If the casserole is very cold from the refrigerator, it may need a few extra minutes in the oven.

Can I use frozen spinach?

Yes. Thaw the frozen spinach completely and squeeze out excess water before adding it to the chicken mixture.

This is important because excess water can make the casserole loose or watery.

Can I use rotisserie chicken?

Absolutely. Rotisserie chicken is one of the easiest options for this recipe. Remove the skin and bones, then shred the cooked chicken before mixing it with the other ingredients.

Can I make this casserole without breadcrumbs?

Yes. Breadcrumbs are completely optional. The casserole will still have a creamy, cheesy topping without them.

For a gluten-free crunchy topping, you can use almond flour instead.

Can I make this recipe low-carb?

Yes. Simply leave out the optional breadcrumbs and choose ingredients that fit your preferred low-carb plan.

Can I add cottage cheese?

Yes. A small amount of plain cottage cheese can be blended with the Greek yogurt to make the creamy base even richer.

Can I add more vegetables?

Yes. You can add chopped mushrooms, bell peppers, broccoli, or additional spinach. Be careful with watery vegetables because they can affect the final texture.

Does this taste like spinach artichoke dip?

The flavors are similar because the casserole uses spinach, artichokes, creamy Greek yogurt, and cheese. The shredded chicken makes it more substantial and suitable as a complete dinner.

Can I make it spicy?

Yes. Add red pepper flakes, cayenne pepper, or diced jalapeño to the chicken mixture before baking.

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This High Protein Spinach and Artichoke Chicken Casserole combines shredded chicken, creamy Greek yogurt, spinach, artichoke hearts, mozzarella, and Parmesan in one easy baked dinner. It is simple to assemble, requires basic ingredients, and works especially well when you want a comforting meal that can also be prepared ahead.

For the best texture, drain the artichokes and spinach well, use a flavorful shredded chicken, and let the casserole rest for a few minutes after baking before serving.